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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T33701 | NM-3 | NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3 | Apoptosis , Reactive Oxygen Species |
NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting the p... | |||
TQ0132 | A 419259 trihydrochloride | RK 20449 trihydrochloride | Src |
A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn). | |||
T10718L | CCT241533 hydrochloride | Chk | |
CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM). | |||
T10708 | CCR1 antagonist 6 | CCR | |
CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM). | |||
T10740 | CDK8-IN-1 | CDK | |
CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM). | |||
T2272 | BPR1J-097 | BPR1J097 | FLT |
BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM). | |||
T14681 | BMS-935177 | BTK | |
BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM. | |||
T2634 | Ro3280 | RO 3280,Ro5203280 | PLK |
Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM). | |||
TQ0187 | SR-3677 | ROCK , Autophagy | |
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM). | |||
T6756 | AMG 925 | FLT , CDK | |
AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. | |||
T2514 | Linifanib | ABT-869,RG3635,AL-39324 | Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy |
Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife... | |||
T10244 | ACY-1083 | HDAC | |
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy. | |||
T7202 | ITE | AhR , Aryl Hydrocarbon Receptor | |
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity. | |||
TP1380 | Galanin (1-16), mouse, porcine, rat | Neuropeptide Y Receptor | |
Galanin (1-16), mouse, porcine, rat is a hippocampal galanin receptor agonist(Kd = 3 nM) with high biological activity on locus coeruleus neurons. | |||
T2251 | NVP-TAE 684 | TAE684 | Apoptosis , ALK |
NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM). | |||
T11696 | Ivachtin | Caspase-3 Inhibitor VII | Caspase |
Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases. | |||
TQ0031 | Nedisertib | M3814 | DNA-PK |
Nedisertib (M3814) (M3814) is a specific inhibitor of DNA-dependent Protein Kinase (DNA-PK, IC50: <3 nM). | |||
T2710 | TCS 1102 | OX Receptor | |
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors). | |||
TQ0263 | EPZ031686 | EPZ-031686 | Histone Methyltransferase |
EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer. | |||
T6309 | AZ960 | AZ 960 | Apoptosis , Virus Protease , JAK , Parasite |
AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM). |